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For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

CohBar Announces CB4211 Phase 1a/1b Results Selected for Late Breaker Presentation at The Liver Meeting 2021 | FirstWord Pharma Updated Oct 2021

Can assist in cartilage repair

The peptide comes as a lyophilized powder that must be reconstituted with bacteriostatic water before injection

Eloralintide Phase 2: 263 adults, 48 weeks, mean weight reductions of 9.5%-20.1% versus 0.4% for placebo, with about 20.1% at the 9 mg dose